Figure 4

BDNF levels in the cortex. (a) Quantification of BDNF levels using ELISA, results represent picogram BDNF measured normalized to milligram cortex tissue (*P<0.05, **P<0.01). (b, c) Immunohistochemistry against BDNF in cortical brain slices of mice transplanted with MSCs (red, PKH pre-labeled human cells; green, BDNF signal; yellow, merge). BDNF, brain-derived neurotrophic factor; ELISA, enzyme-linked immunosorbent assay; MSCs, mesenchymal stem cells; PCP, phencyclidine.