Figure 1

(a) Scattergram of total hippocampal volume for subjects homozygous for the val allele (val/val, n=103) and carriers of a met allele (val/met, n=54). Horizontal lines indicate the mean for each group. Data are adjusted for age, gender, number of years of education, selective serotonin reuptake inhibitor use, alcohol use and scan site. (b) Coronal and sagittal views and a statistical map of t-transformed hippocampal volume differences by BDNF val⁶⁶met genotype. Note: voxelwise analyses confirmed these findings with the peak voxel located in the posterior part of the hippocampus (MNI coordinate: right hippocampus: (x=18, y=−33, z=8 and x=21, y=−30, z=−4), Z=3.61/3.42, k=29/17; left hippocampus: (x=−18, y=−36, z=8), Z=3.17, k=4).