Figure 2

(a) Mean total hippocampal activity during encoding by stimulus valence for subjects homozygous for the val allele (val/val, n=103) and carriers of a met allele (val/met, n=54). (b) Mean total hippocampal activity during the encoding of negative words by childhood abuse before the age of 16 years (yes vs no) for subjects homozygous for the val allele (55 abused, 48 non abused) and carriers of a met allele (25 abused, 29 non abused). The val⁶⁶met–childhood abuse interaction effect is significant at P=0.01. Error bars reflect the s.e.m. Data are adjusted for age, gender, number of years of education, selective serotonin reuptake inhibitor use, alcohol use and scan site. ^*P<0.05.