Table 1 Twenty-eight schizophrenia susceptibility genes are also implicated in other neuropsychiatric disorders that exhibit neuroanatomical or functional abnormalities in the hippocampal formation
Genes | Diseases | Significant differences in expression between newborn and adult monkeys | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  |  |  |  |  |  |  | Adult>newborn | Newborn>adult | ||||||||
 | SCZ | EPI | ASD | DEP | PSY | BP | ALZ | WIL | EC | DG | CA3 | CA1 | Sub | EC | DG | CA3 | CA1 | Sub |
SLC6A4 | x | x | x | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
BDNF | x | x | Â | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | x |
APOE | x | x | Â | x | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | x | x | x | Â |
SLC6A3 | x | Â | Â | x | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MTHFR | x | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
DISC1 | x | Â | x | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CHRNB2 | x | x | Â | Â | Â | Â | x | Â | Â | x | Â | Â | Â | Â | x | Â | Â | Â |
HTR2A | x | Â | Â | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MAOA | x | Â | Â | Â | x | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | x | x | Â |
DRD2 | x | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | Â | x | Â |
SLC1A2 | x | Â | Â | Â | x | Â | Â | Â | x | Â | Â | Â | x | Â | x | x | x | Â |
COMT | x | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | x | x | x | x | Â |
AR | x | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â |
GABBR1 | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | x | Â |
GABRG2 | x | x | Â | Â | Â | Â | Â | Â | x | x | Â | Â | Â | Â | Â | x | x | Â |
IL10 | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
IL1B | x | x | Â | Â | Â | Â | Â | Â | Â | Â | x | x | Â | Â | Â | Â | Â | Â |
TNF | x | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
AHI1 | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | Â | x |
DRD5 | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | x | Â |
FOXP2 | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x |
PTPRZ1 | x | Â | x | Â | Â | Â | Â | Â | Â | x | Â | Â | Â | Â | x | x | x | Â |
RELN | x | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | Â | Â | Â |
GRM3 | x | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | x | x | Â | Â | Â |
DAO | x | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | x | Â |
GRIN2B | x | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | Â | x | x | x | Â |
STX1A | x | Â | Â | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â | x | Â | x |
SLC18A1 | x | Â | Â | x | Â | Â | Â | Â | Â | Â | x | Â | Â | Â | Â | Â | Â | Â |
Total number | 28 | 10 | 7 | 7 | 8 | 6 | 2 | 1 | 2 | 4 | 2 | 2 | 1 | 2 | 9 | 11 | 12 | 4 |
Percentage | Â | 36% | 25% | 25% | 29% | 21% | 7% | 4% | 7% | 14% | 7% | 7% | 4% | 7% | 32% | 39% | 43% | 14% |