Table 1 Twenty-eight schizophrenia susceptibility genes are also implicated in other neuropsychiatric disorders that exhibit neuroanatomical or functional abnormalities in the hippocampal formation

From: Developmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation

Genes

Diseases

Significant differences in expression between newborn and adult monkeys

         

Adult>newborn

Newborn>adult

 

SCZ

EPI

ASD

DEP

PSY

BP

ALZ

WIL

EC

DG

CA3

CA1

Sub

EC

DG

CA3

CA1

Sub

SLC6A4

x

x

x

x

x

             

BDNF

x

x

 

x

 

x

          

x

x

APOE

x

x

 

x

  

x

       

x

x

x

 

SLC6A3

x

  

x

x

x

            

MTHFR

x

x

 

x

              

DISC1

x

 

x

  

x

            

CHRNB2

x

x

    

x

  

x

    

x

   

HTR2A

x

  

x

x

             

MAOA

x

   

x

    

x

     

x

x

 

DRD2

x

   

x

         

x

 

x

 

SLC1A2

x

   

x

   

x

   

x

 

x

x

x

 

COMT

x

   

x

        

x

x

x

x

 

AR

x

   

x

      

x

      

GABBR1

x

x

             

x

x

 

GABRG2

x

x

      

x

x

     

x

x

 

IL10

x

x

                

IL1B

x

x

        

x

x

      

TNF

x

x

                

AHI1

x

 

x

            

x

 

x

DRD5

x

 

x

            

x

x

 

FOXP2

x

 

x

              

x

PTPRZ1

x

 

x

      

x

    

x

x

x

 

RELN

x

 

x

           

x

   

GRM3

x

    

x

       

x

x

   

DAO

x

    

x

          

x

 

GRIN2B

x

    

x

        

x

x

x

 

STX1A

x

      

x

       

x

 

x

SLC18A1

x

  

x

      

x

       

Total number

28

10

7

7

8

6

2

1

2

4

2

2

1

2

9

11

12

4

Percentage

 

36%

25%

25%

29%

21%

7%

4%

7%

14%

7%

7%

4%

7%

32%

39%

43%

14%

  1. Abbreviations: ALZ, Alzheimer's disease; ASD, autism spectrum disorder; BP, bipolar disorder; DEP, major depressive disorder; DG, dentate gyrus; EC, entorhinal cortex; EPI, temporal lobe epilepsy; PSY, psychopathy antisocial personality disorder; SCZ, schizophrenia; Sub, subiculum; WIL, Williams syndrome.