Figure 3 | Translational Psychiatry

Figure 3

From: Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

Figure 3

Lack of amyloid deposition in 15-month-old E22ΔAβ mice. (a–d) Immunostaining with antibody 6E10 reveals a complete absence of extracellular amyloid deposits in 15-month-old E22ΔAβ mice (a: cortex; b: hippocampus). In contrast, arcAβ mice show a massive extracellular amyloid deposition at that age (c: cortex; d: hippocampus). Scale bars: 250 μm (a–d). Aβ, amyloid β.

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