Figure 4 | Translational Psychiatry

Figure 4

From: Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

Figure 4

Aged E22ΔAβ mice develop congophilic amyloid angiopathy (CAA) at 24 months. (a+b) Immunostaining of amyloid-laden leptomeningeal vessels with polyclonal anti-amyloid antibody directed against human pan-Aβ in the cortex (a) and cerebellum (b) of a 24-month-old E22ΔAβ mouse. (c+d) Vascular amyloid deposits are thioflavin S (c) and Congo red positive (d). Note the classical apple-green birefringence of Congo red-stained vessels under polarized light (d). (e+f) Immunostainings with Aβ40-specific monoclonal antibody BA27 (e) and Aβ42-specific monoclonal antibody BC05 (f) reveal that Aβ40 is the dominant Aβ species deposited in the vessel walls. Scale bars: 125 μm (a+b) and 40 μm (c–f). Aβ, amyloid β.

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