Figure 5 | Translational Psychiatry

Figure 5

From: Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

Figure 5

Intraneuronal amyloid β (Aβ) consists of fibrillar oligomers bearing a ‘toxic turn’ conformation. (a–d) Immunostaining with polyclonal OC antibody directed against fibrillar Aβ oligomers reveals age-dependent accumulation of intracellular oligomeric deposits in cortical (a and b) and CA1 hippocampal neurons (c and d). Note the temporal change of intraneuronal oligomers from rather diffuse and smaller dot-like aggregates at 3 months of age (a and c) to bigger and more compact deposits at 15 months of age (b and d). (e and f) Conformation-dependent monoclonal antibody 11A1 directed against the turn between positions 22 and 23 of the Aβ sequence stains hippocampal (e) and cortical (f) intraneuronal aggregates (representative immunostaining in a 15-month-old E22ΔAβ mouse). Scale bar: 40 μm (a–f).

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