Figure 6 | Translational Psychiatry

Figure 6

From: Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

Figure 6

Early cognitive deficits in E22ΔAβ mice. (a) Cognitive assessment in the Y-maze demonstrates a significant decrease in the percentage spatial alternation rate for E22ΔAβ mice as compared with their wild-type (wt) littermates at 3, 6 and 9 months of age (P<0.05 for all comparisons; Student’s t-test). (b) Assessment of Barnes maze spatial learning at the age of 3 months reveals that both wild-type and E22ΔAβ transgenic mice show successful learning over the 4 days of training. However, E22ΔAβ mice, as compared with wild-type littermates, show significantly higher latencies to escape on day 3 (P=0.01) and day 4 (P=0.03), with similar but nonsignificant trends on day 1 (P=0.096) and day 2 (P=0.095) (analysis of variance (ANOVA), followed by post hoc Fisher’s least significant difference (LSD) analysis). (c and d) Qualitative assessment of Barnes maze search strategies reveals a decrease in spatial and relative increase in serial search strategies in 3-month-old E22ΔAβ mice (d) in comparison to wild-type control mice (c). n=22–24 per group. Aβ, amyloid β.

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