Figure 1 | Translational Psychiatry

Figure 1

From: Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability

Figure 1

Location and genomic features of the human PER2 (Period 2) gene. (a, Upper panel) The locus of the chromosome 2 (q37.3) corresponding to the PER2 gene (red box). A snapshot of the PER2 locus (UCSC Genome Browser, hg19) illustrates its major genomic features, including high recombination rate (dark gray bar on the top), GC enrichment (GC % shown in full), multiple single-nucleotide polymorphisms (SNPs) and tandem repeats. Polymorphic variable number tandem repeat (VNTR) (red circle) resides immediately upstream of intron 3 (green arrow). (b) The light blue arrowheads indicate positions of the primers used to amplify VNTR region. As evident from the conservation tracks, the consensus of the polymorphic tandem repeat (black bar at the bottom) is lacking in the other species, including primates (yellow arrows are pointing to boundaries of a gap in the Rhesus macaque sequence).

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