Table 3 HWE equilibrium testing

From: Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability

Genotype

Sample

African Americans

Non-Africans

 

Obs

Exp

Obs

Exp

Obs

Exp

(a) Multi-allelic model

4R/4R

346

331

144

138

202

199

4R/3R

105

125

85

91

20

24

3R/3R

23

12

20

15

3

1

4R/2R

25

35

22

27

3

5

3R/2R

5

7

5

9

0

0

2R/2R

7

1

6

1

1

0

 

χ2=56.5

 

χ2=21.1

 

χ2=43.3

 

(b) Bi-allelic model

4R/4R

346

334.05

144

138.75

202

199.75

4R/3R

105

126.9

85

93.5

20

24.5

3R/3R

23

12.05

20

15.75

3

0.75

 

χ2=14.08

 

χ2=2.05

 

χ2=7.58

 
  1. Abbreviations: Exp, expected; HWE, Hardy–Weinberg equilibrium; Obs, observed.
  2. HWE was calculated using popgen genetic applet (a, multiallelic markers) and OEGE software (b, bi-allelic markers).
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