Table 5 Striatal D2R binding in PER2 genotype groups

From: Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability

 

PER2 genotype

F (d.f.)

P-value

Nonicept

Observed power

 

4R/4R

4R/3R

3R/3R

Rare

    

Caudate

2.7±0.06

2.54±0.06

2.76±0.17

2.14±0.2

(7,44)=9.18

<0.001

64.3

1

 

30

15

3

4

    

Putamen

3.31±0.07

3.08±0.1

3.46±0.22

2.66±0.25

(7,44)=8.46

<0.001

59.4

1

 

30

15

3

4

    

Ventral striatum

2.91±0.09

2.55±0.13

3.02±0.25

2.31±0.29

(7,36)=4.13

0.002

28.9

0.97

 

24

13

3

4

    
  1. Abbreviations: ANCOVA, analysis of covariance; D2R, dopamine D2 receptor; d.f., degrees of freedom; PER2, Period 2.
  2. Values of DRD2 binding in striatal regions by PER2 genotype groups are shown as model adjusted means±s.e. based on the non-transformed DRD2 binding data.
  3. F-value, P-value (significance) and observed power (computed using α=0.05) values are from ANCOVA. η is a nonicept parameter.
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