Table 2 Gene ontology analysis of dysregulated genes (FDR⩽5%)
Category | ID | Term | Genes | Count | % | P-value |
|---|---|---|---|---|---|---|
MDE 0w vs C (FC⩾1.50) | ||||||
Biological process | GO:0008219 | Cell death | API5, FIG4, GSPT1, ARHGEF6, APAF1, ELMO2, HIPK3, PPT1 , PDCD6IP, PKM2, SGPP1, TPP1 , KRAS | 13 | 12.4 | 1.6E-3 |
Biological process | GO:0007033 | Vacuole organization | FIG4, HEXB, PPT1, TPP1 | 4 | 3.8 | 1.9E-3 |
Cellular component | GO:0016023 | Cytoplasmic membrane-bounded vesicle | AGFG1, DENND1A, CHIC2, HEXB, HGF, MAPKAP1, PPT1 , PDCD6IP, SNAP23, TPP1 | 10 | 9.5 | 3.3E-3 |
Molecular function | GO:0000166 | Nucleotide binding | ACTBL2 , ACSL4, APAF1, ARL8B, ATP2A2 , CMPK1, CTBP1, CELF2 , GNAQ, GSPT1, HNRNPF, HIPK3, KRAS, MAT2A, MAPK6, MYH9, PKM2, POTEE, POTEF, POTEKP , PTBP1, RAB18, RAP2C, UBE2E2, UBE2H | 25 | 23.8 | 4.2E-3 |
MDE 0w vs C (FC⩽−1.50) | ||||||
Cellular component | GO:0000786 | Nucleosome | HIST1H1A , HIST1H1D, HIST1H1E , HIST1H3F/HIST2H3A/HIST1H3D, HIST1H4E /HIST1H4A/HIST1H4K/HIST1H4L | 5 | 8.9 | 8.6E-6 |
Cellular component | GO:0044427 | Chromosomal part | CENPP, HIST1H1A , HIST1H1D, HIST1H1E , HIST1H3F/HIST2H3A/HIST1H3D, HIST1H4E /HIST1H4A/HIST1H4K/HIST1H4L | 6 | 10.7 | 1.1E-3 |
Biological process | GO:0006325 | Chromatin organization | HIST1H1A , HIST1H1D, HIST1H1E , HIST1H3F/HIST2H3A/HIST1H3D, HIST1H4E /HIST1H4A/HIST1H4K/HIST1H4L, TLK2 | 6 | 10.7 | 1.1E-3 |
MDE 8w (responders) vs C (FC⩾1.50) | ||||||
Biological process | GO:0007040 | Lysosome organization | HEXB, PPT1, TPP1 | 3 | 5.5 | 2.6E-3 |
MDE 8w (responders) vs C (FC⩽−1.50) | ||||||
Biological process | GO:0006323 | DNA packaging | ASH1L, HIST1H1C, HIST1H1D, HIST1H1E , HIST1H3F/HIST1H3D, HIST1H4J/HIST1H4K/HIST1H4L/ HIST1H4E /HIST1H4A | 6 | 12.5 | 7.4E-6 |
Biological process | GO:0006334 | Nucleosome assembly | HIST1H1C, HIST1H1D, HIST1H1E , HIST1H3F/HIST1H3D, HIST1H4J/HIST1H4K/HIST1H4L/ HIST1H4E /HIST1H4A | 5 | 10.4 | 4.4E-5 |
Biological process | GO:0051276 | Chromosome organization | ASH1L, HIST1H1C, HIST1H1D, HIST1H1E , HIST1H3F/HIST1H3D, HIST1H4J/HIST1H4K/HIST1H4L/ HIST1H4E /HIST1H4A, SMC1A, TLK2 | 8 | 16.7 | 1.1E-4 |
Biological process | GO:0006325 | Chromatin organization | ASH1L, HIST1H1C, HIST1H1D, HIST1H1E , HIST1H3F/HIST1H3D, HIST1H4J/HIST1H4K/HIST1H4L/ HIST1H4E /HIST1H4A, TLK2 | 7 | 14.6 | 2.2E-4 |
Biological process | GO:0034622 | Cellular macromolecular complex assembly | HIST1H1C, HIST1H1D, HIST1H1E , HIST1H3F/HIST1H3D, HIST1H4J/HIST1H4K/HIST1H4L/ HIST1H4E /HIST1H4A, RPL24 | 6 | 12.5 | 8.3E-4 |
Biological process | GO:0048562 | Embryonic organ morphogenesis | CLIC5, EDN1, HOXA3, HOXA7 | 4 | 8.3 | 3.7E-3 |
