Table 3 Symptom remission by antidepressant and ABCB1 genotype

From: ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

dbSNP ID

N

Symptom remission (HDRS≤7) according to genotype

OR a

95% CI

P-value

Escitalopram

 rs1045642 (C3435T)

57

CC: 8/13 (61.5%)

CT: 16/29 (55.2%)

TT: 11/15 (73.3%)

1.25

0.52–3.02

0.614

 rs2032582 (G2677T/A)

57

CC: 6/12 (50.0%)

CT: 22/35 (61.0%)

TT: 8/10 (80.0%)

1.84

0.44–4.63

0.192

 rs1128503 (C1236T)

57

CC: 8/14 (57.1%)

CT: 18/30 (60.0%)

TT: 9/13 (69.2%)

1.16

0.46–2.92

0.748

Venlafaxine

 rs1045642 (C3435T)

41

CC: 1/8 (12.5%)

CT: 11/18 (61.1%)

TT: 11/15 (73.3%)

6.69

1.72–25.9

0.006b

 rs2032582 (G2677T/A)

41

CC: 4/9 (44.4%)

CT: 8/20 (40.0%)

TT: 10/12 (83.3%)

4.04

1.27–12.8

0.018

 rs1128503 (C1236T)

41

CC: 4/9 (44.4%)

CT: 6/14 (42.9%)

TT: 12/18 (66.6%)

1.92

0.77–4.80

0.165

  1. Abbreviations: ABCB1, ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1; CI, confidence interval; HDRS, 17-item Hamilton Depression Rating Scale; OR, odds ratio; SNP, single-nucleotide polymorphism.
  2. aAdjusted for ethnicity and education.
  3. bSignificant after Bonferroni correction (P<0.017 needed).
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