Table 4 Average antidepressant dose (mg) among remitters by ABCB1 genotypea

From: ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

SNP

N

Venlafaxine

N

Escitalopram

rs1045642 (C3435T)

 CC

1

150 (0)

8

19 (8)

 CT

11

150 (70)

16

24 (7)

 TT

11

120 (72)

11

11 (3)

 P-value

 

0.639

 

0.0001b (TT<CT and CC)

rs2032582 (G2677T/A)

    

 CC

4

131 (38)

6

20 (6)

 CT

8

150 (95)

21

22 (8)

 TT

10

130 (68)

7

10 (0)

 P-value

 

0.851

 

0.003b (TT<CT and CC)

rs1128503 (C1236T)

    

 CC

4

131 (38)

8

18 (7)

 CT

6

165 (98)

18

23 (8)

 TT

12

125 (67)

9

11 (3)

 P-value

 

0.577

 

0.001b (TT<CT and CC)

  1. Abbreviations: ABCB1, ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1; HDRS, 17-item Hamilton Depression Rating Scale; SNP, single-nucleotide polymorphism.
  2. aRemission defined as an HDRS score ≤7.
  3. bSignificant after Bonferroni correction (P<0.017 needed).
Back to article page