Table 2 Spatial localization of significant clusters showing a negative correlation between GM density and serum NSE concentration for the group of 27 overweight and obese subjects (BMI>25) with a voxel threshold of P<0.005 and a cluster threshold of P<0.05, FDR-corrected

From: Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study

P FDR

x

y

z

Hem

T

Assigned to

Probability (%)

Range (%)

0.017

−28

−16

−36

L

5.27

Hippocampus (EC)

80

(50–100)

 

−28

3

−38

L

4.19

Hippocampus (EC)

40

(20–60)

 

−27

14

−45

L

3.67

0.033

30

−16

−39

R

4.49

 

27

4

−38

R

4.28

Hippocampus (EC)

90

(60–100)

 

24

−17

−28

R

4.22

Hippocampus (EC)

100

(80–100)

0.003

−32

−60

−33

L

5.29

Cerebellum, Lobule VIIa Crus I (Hem)

75

(59–86)

 

−52

−54

−38

L

3.79

Cerebellum, Lobule VIIa Crus I (Hem)

94

(91–100)

 

−45

−46

−44

L

3.40

Cerebellum, Lobule VIIa Crus I (Hem)

56

(56–78)

0.000

56

−63

−32

R

6.01

Cerebellum, Lobule VIIa Crus I (Hem)

86

(61–100)

 

54

−60

−47

R

5.99

Cerebellum, Lobule VIIa Crus I (Hem)

74

(73–83)

 

36

−64

−33

R

5.20

Cerebellum, Lobule VIIa Crus I (Hem)

100

(91–100)

  1. Abbreviations: BMI, body mass index; FDR, false discovery rate; GM, gray matter; Hem, Hemisphere; L, left; MNI, Montreal Neurological Institute; NSE, neuron-specific enolase; PFDR, cluster-level FDR-corrected P-value; R, right; x,y,z, MNI coordinates.
  2. Anatomical localization was obtained using the SPM Anatomy toolbox. Right columns show the probability of finding the assigned anatomical structure with the local cluster maximum. Range shows the range of those probabilities including the surrounding voxels.