Figure 3
From: Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling
Adenosine A1R are required for the beneficial effects of sleep deprivation on depressive-like behavior. (a) A1R immunohistochemistry in +/+ and A1R−/− brain. (b) Heat maps of representative performance of +/+, A1R−/− and i.c.v. CPT-treated mice during the last 4 min of the forced-swim test. Knockout of A1R, or i.c.v. CPT, prevents the beneficial effects of sleep deprivation on depressive-like behavior in the forced swim (c) and tail-suspension tests (d). ***P⩽0.001.
