Figure 5
From: Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling
Activation of A1R with CCPA leads to sustained antidepressive-like behaviors. (a) Representative heatmaps showing dwell time during the last 4 min of the forced-swim test following CCPA treatment and sleep deprivation (12 h). (b) CCPA significantly reduces immobility in the forced-swim test, an effect that is sustained for 36 h following the onset of CCPA administration. (c) Validation of forced-swim test results using an additional test of depressive-like symptoms, the sucrose consumption test. *P⩽0.05, **P⩽0.01.
