Table 3 Genotype counts and association statistics

From: Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study

SNP

Study subgroup

Genotypes (and frequencies) cases

P -value Trend test, d.f.=1

P -value (OR, (95% CI))

  

Genotypes (and frequencies) controls

 

Log additive, adjusted according to sex

rs1062613

 

CC (%)

CT (%)

TT (%)

  
 

Bosnia-Herzegovina

70 (58)

44 (37)

6 (5)

  
  

81 (71)

30 (27)

2 (2)

0.073

0.025 (1.72, (1.06–2.80))

 

Germany

224 (62)

124 (34)

15 (4)

  
  

469 (62)

260 (34)

30 (4)

0.99

0.937 (0.99, (0.79–1.24))

 

Poland

306 (70)

114 (26)

16 (4)

  
  

335 (61)

180 (33)

33 (6)

0.01

0.002 (0.71, (0.57–0.89))

 

Romania

144 (63)

70 (31)

13 (6)

  
  

142 (65)

69 (31)

8 (4)

0.579

0.524 (1.11, (0.8–1.53))

 

Russia

205 (63)

109 (33)

11 (3)

  
  

205 (63)

105 (32)

14 (4)

0.808

0.865 (0.98, (0.74–1.28))

 

Spain

167 (57)

107 (36)

20 (7)

  
  

207 (52)

157 (39)

34 (9)

0.416

0.190 (0.85, (0.67–1.08))

rs3831455

 

ins/ins (%)

ins/del (%)

del/del (%)

  
 

Bosnia-Herzegovina

97 (81)

21 (18)

2 (2)

0.312

0.195 (0.69, (0.40–1.21))

  

82 (73)

29 (26)

2 (2)

  
 

Germany

278 (77)

80 (22)

5 (1)

0.702

0.477 (1.11, (0.84–1.47))

  

594 (78)

158 (21)

7 (1)

  
 

Poland

328 (75)

99 (22)

9 (2)

0.221

0.099 (1.26, (0.96–1.65))

  

430 (79)

107 (20)

6 (1)

  
 

Romania

174 (77)

46 (20)

6 (3)

0.591

0.812 (0.95, (0.65–1.40))

  

162 (75)

52 (24)

3 (1)

  
 

Russia

252 (78)

63 (19)

9 (3)

0.204

0.239 (1.22, (0.87–1.70))

  

261 (81)

59 (18)

4 (1)

  
 

Spain

245 (83)

47 (16)

3 (1)

0.597

0.295 (0.83, (0.58–1.18))

  

318 (80)

75 (19)

5 (1)

  

rs1176744

 

AA (%)

AC (%)

CC (%)

  
 

Bosnia-Herzegovina

54 (44)

57 (46)

13 (11)

0.3

0.152 (1.34, (0.90–1.99))

  

61 (54)

44 (39)

9 (8)

  
 

Germany

191 (51)

152 (41)

31 (8)

0.321

0.178 (0.87, (0.72–1.06))

  

355 (47)

335 (44)

73 (10)

  
 

Poland

235 (54)

157 (36)

45 (10)

0.017

0.037 (0.82, (0.68–0.99))

  

249 (45)

245 (44)

58 (11)

  
 

Romania

120 (51)

93 (40)

22 (9)

0.367

0.857 (0.97, (0.73–1.30))

  

110 (48)

105 (46)

16 (7)

  
 

Russia

154 (47)

140 (43)

34 (10)

0.889

0.950 (1.01, (0.80–1.27))

  

151 (45)

154 (46)

28 (8)

  
 

Spain

128 (43)

136 (46)

32 (11)

0.013

0.005 (0.73, (0.59–0.91))

  

142 (36)

181 (46)

73 (18)

  
  1. Abbreviations: CI, confidence interval; d.f., degrees of freedom; OR, odds ratio; SNP, single nucleotide polymorphism.
  2. Frequencies (%) were rounded off to the nearest whole number. P-values are displayed in bold if withstanding Bonferroni correction, nominally significant P-values are shown in italics.
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