Table 4 Interaction between NGF rs6330 and 5-HTTLP R in predicting primary anxiety disorder response (NGF rs6330 coded as CC=−1; CT=0, TT=1; 5-HTTLPR coded as LL/LS=0; SS=1)
From: Neurotrophic gene polymorphisms and response to psychological therapy
Predictor variable | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
NGF rs6330 | 0.58 (0.40–0.84) | 0.004 | 0.57 (0.38–0.85) | 0.006 | 0.59 (0.39–0.89) | 0.013 |
5-HTTLPR | 0.38 (0.18–0.80) | 0.011 | 0.39 (0.18–0.85) | 0.017 | 0.36 (0.16–0.82) | 0.015 |
rs6330 × 5-HTTLPR | 1.12 (0.40–3.12) | 0.823 | ||||
Time (linear) | 0.18 (0.02–1.76) | 0.140 | 0.18 (0.02–1.76) | 0.141 | 0.41 (0.04–4.85) | 0.481 |
Time2 (quadratic) | 1.30 (0.95–1.78) | 0.106 | 1.30 (0.95–1.78) | 0.105 | 1.15 (0.82–1.62) | 0.422 |
Age | 0.90 (0.78–1.05) | 0.174 | 0.90 (0.78–1.04) | 0.168 | 0.91 (0.77–1.07) | 0.261 |
Gender | 1.16 (0.69–1.95) | 0.580 | 1.16 (0.69–1.95) | 0.578 | 1.33 (0.74–2.37) | 0.339 |
Site | 1.08 (0.56–2.10) | 0.809 | 1.08 (0.56–2.10) | 0.812 | 0.95 (0.43–2.10) | 0.891 |
Pre-treatment severity | 1.44 (0.98–2.12) | 0.061 | ||||
Comorbid mood disorders | 3.26 (0.93–11.38) | 0.064 | ||||
Maternal psychopathology | 1.04 (1.00–1.09) | 0.066 | ||||
