Figure 2
From: Genome-wide meta-analyses of smoking behaviors in African Americans
Forest and regional plot of rs2036527 with cigarettes smoked per day (CPD) from meta-analyses of the Study of Tobacco in Minority Populations (STOMP) consortia. Forest plot showing effect sizes across studies; I2=41.6%. Regional association plot show single-nucleotide polymorphisms (SNPs) plotted by position on chromosome against −log10 P-value. Estimated recombination rates (from HapMap-CEU) are plotted in light blue to reflect the local linkage disequilibrium (LD) structure on a secondary y axis. The SNPs surrounding the most significant SNP (purple) are color-coded to reflect their LD with this SNP (using pairwise r2 values from HapMap-CEU): orange, r20.8, red; 0.6–0.8, orange; 0.6–0.8; green, 0.4–0.6, light blue, 0.2–0.4; dark blue, <0.2. The blue bars at the bottom of the plot represent the relative size and location of genes in the region. AABC, African American GWAS consortia of Breast cancer; AAPC, African American GWAS consortia of Prostate Cancer; ARIC, Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; CFS, Cleveland Family Study; JHS, Jackson Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis; HANDLS, Healthy Aging in Neighborhoods across the Life Span Study; HYPGEN, Hypertension Genetic Epidemiology Network; WHI, Women's Health Initiative.
