Table 2 SNPs with meta-analytic P-values of <1 × 10−6 for CPD and AOI

From: Genome-wide meta-analyses of smoking behaviors in African Americans

Phenotype

SNP

Chromosome (bp position)

Nearby genes

Alleles *

Coded AF

Sample size (N)

β

s.e.

P-value

I2 (%)

CPD

rs2036527

15 (76638670)

CHRNA5

A/G

0.22

15 554

0.040

0.007

1.84 × 10 −8

41.6

CPD

rs667282

15 (76650527)

CHRNA5

C/T

0.29

15 536

0.033

0.006

1.81 × 10−7

21.7

CPD

rs3101457

1 (242599837)

C1orf100

A/G

0.75

15 513

0.041

0.008

2.63 × 10−7

1.1

CPD

rs938682

15 (76683602)

CHRNA3

A/G

0.71

15 475

0.033

0.006

3.75 × 10−7

17.4

CPD

rs547843

15 (23975140)

LOC503519

C/G

0.65

12 701

−0.035

0.007

6.16 × 10−7

24.2

CPD

rs3813570

15 (76619887)

PSMA4

C/T

0.26

15 543

0.033

0.007

9.85 × 10−7

0.0

AOI

rs1678618

10 (73476294)

SPOCK2

A/G

0.74

16 874

−0.060

0.012

8.25 × 10−7

0.0

AOI

rs1245577

10 (73480920)

SPOCK2

C/G

0.26

16 877

0.060

0.012

8.30 × 10−7

2.6

AOI

rs1612028

10 (73475296)

SPOCK2

C/G

0.75

16 798

−0.060

0.012

9.28 × 10−7

6.3

  1. Abbreviations: AF, allele frequency; AOI, age of smoking initiation; CPD, cigarettes smoked per day; SNP, single-nucleotide polymorphism.
  2. First named allele is coded allele. Coded AF refers to the allele analyzed as the predictor allele; it is not necessarily the minor allele. All SNPs coded to NCBI Build 36/UCSC hg18 forward strand. One SNP (rs2036527) highlighted in bold text achieved genome-wide significance.
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