Table 2 Biological processes (Gene ontology) significantly associated with cis eQTL genes in the frontal cortex of the Array Collection samples
From: Association between SNPs and gene expression in multiple regions of the human brain
Biological process categories | Count | Fraction (%) | P -value |
|---|---|---|---|
GO:0006541–glutamine metabolic process | 6 | 0.13 | 5.00E−05 |
GO:0009064–glutamine family amino acid metabolic process | 8 | 0.17 | 1.50E−04 |
GO:0006412–translation | 19 | 0.41 | 5.10E−04 |
GO:0046907–intracellular transport | 28 | 0.60 | 1.80E−03 |
GO:0006414–translational elongation | 9 | 0.19 | 2.00E−03 |
GO:0009069–serine family amino acid metabolic process | 5 | 0.11 | 2.50E−03 |
GO:0034613–cellular protein localization | 19 | 0.41 | 5.50E−03 |
GO:0070727–cellular macromolecule localization | 19 | 0.41 | 5.80E−03 |
GO:0002474–antigen processing and presentation of peptide antigen via MHC class I | 4 | 0.09 | 6.00E−03 |
GO:0002483–antigen processing and presentation of endogenous peptide antigen | 3 | 0.06 | 7.10E−03 |
GO:0019885–antigen processing and presentation of endogenous peptide antigen via MHC class I | 3 | 0.06 | 7.10E−03 |
GO:0006508–proteolysis | 37 | 0.79 | 7.60E−03 |
GO:0006605–protein targeting | 12 | 0.26 | 9.50E−03 |
GO:0006886–intracellular protein transport | 17 | 0.36 | 1.10E−02 |
GO:0019882–antigen processing and presentation | 7 | 0.15 | 1.10E−02 |
GO:0046777–protein amino acid autophosphorylation | 7 | 0.15 | 1.20E−02 |
GO:0015031–protein transport | 28 | 0.60 | 1.30E−02 |
GO:0019883–antigen processing and presentation of endogenous antigen | 3 | 0.06 | 1.30E−02 |
GO:0045184–establishment of protein localization | 28 | 0.60 | 1.40E−02 |
GO:0051603–proteolysis involved in cellular protein catabolic process | 23 | 0.49 | 1.70E−02 |
GO:0044257–cellular protein catabolic process | 23 | 0.49 | 1.70E−02 |
GO:0043632–modification-dependent macromolecule catabolic process | 22 | 0.47 | 2.00E−02 |
GO:0019941–modification-dependent protein catabolic process | 22 | 0.47 | 2.00E−02 |
GO:0001510–RNA methylation | 3 | 0.06 | 2.00E−02 |
GO:0044265–cellular macromolecule catabolic process | 26 | 0.56 | 2.30E−02 |
GO:0030163–protein catabolic process | 23 | 0.49 | 2.40E−02 |
GO:0009070–serine family amino acid biosynthetic process | 3 | 0.06 | 2.40E−02 |
GO:0048002–antigen processing and presentation of peptide antigen | 4 | 0.09 | 2.40E−02 |
GO:0008104–protein localization | 30 | 0.64 | 2.50E−02 |
GO:0007143–female meiosis | 3 | 0.06 | 2.90E−02 |
GO:0044271–nitrogen compound biosynthetic process | 14 | 0.30 | 3.20E−02 |
GO:0006607–NLS-bearing substrate import into nucleus | 3 | 0.06 | 3.30E−02 |
GO:0034660–ncRNA metabolic process | 11 | 0.24 | 3.50E−02 |
GO:0006625–protein targeting to peroxisome | 3 | 0.06 | 3.80E−02 |
GO:0043574–peroxisomal transport | 3 | 0.06 | 4.40E−02 |
GO:0009057–macromolecule catabolic process | 26 | 0.56 | 4.70E−02 |
GO:0006399–tRNA metabolic process | 7 | 0.15 | 5.00E−02 |
