Figure 4 | Translational Psychiatry

Figure 4

From: Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory

Figure 4

Adenylyl cyclase 8 (AC8) in the forebrain is sufficient for CA1 LTP (long-term potentiation). (a) Averaged representative traces of pre-tetanus (black) and 80 min post-tetanus (red), four tetanic trains of 100 Hz (200 ms duration, 6 s interpulse interval). Potentiation was measured by % field EPSP (excitatory post-synaptic potential) slope relative to baseline. (b) EPSP responses at 1 min post-HFS (high-field stimulation) demonstrate that double-knockout (DKO) mice (open circles, n=7) have dampened potentiation relative to WT mice as measured by % field EPSP slope (closed circles, n=7; % EPSP slope in DKO vs WT 1 min post-HFS, P<0.05). However, replacing AC8 within the forebrain is sufficient to restore initial LTP deficits as seen in the AC8 Rescue mice (grey circles, n=7; % EPSP slope in AC8 Rescue vs WT 1 min post-HFS, P>0.05). Scale bar 2 mV, 10 ms.

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