Table 1 Factor loadings for side effect factors

From: Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D

System

Item

GSE

Tolerability

Dizziness

Sexual

Visionhearing

GI

Diarrhea

0.24

    
 

Constipation

0.27

    
 

Dry mouth

0.38

    
 

Nausea/vomiting

0.31

    
 

GI tolerability

 

0.55

   

Heart

Palpitations

0.29

    
 

Dizziness on standing

0.58

 

0.83

  
 

Chest pain

0.35

    
 

Heart tolerability

 

0.58

0.74

  

Skin

Rash

0.23

    
 

Increased perspiration

0.3

    
 

Itching

0.38

    
 

Dry skin

0.35

    
 

Skin tolerability

 

0.49

   

CNS

Headache

0.37

    
 

Tremors

0.32

    
 

Poor coordination

0.43

    
 

Dizziness

0.56

 

0.68

  
 

CNS tolerability

 

0.60

   

VisHear

Blurred vision

0.44

   

0.65

 

Ringing in ears

0.35

   

0.63

 

Eyesear tolerability

 

0.51

  

0.92

GenUrin

Difficulty urinating

0.25

    
 

Painful urination

0.21

    
 

Menstrual irregularity

0.08

    
 

Frequent urination

0.33

    
 

GenUrin. tolerability

 

0.45

   

Sleep

Difficulty sleeping

0.3

    
 

Sleeping too much

0.07

    
 

Sleep tolerability

 

0.42

   

Sex

Loss of sexual desire

0.26

  

0.65

 
 

Trouble achieving orgasm

0.18

  

0.56

 
 

Trouble with erections

0.22

  

0.44

 
 

Sex tolerability

 

0.35

 

0.88

 
 

α

0.74

0.72

0.80

0.71

0.75

  1. Abbreviations: CNS, central nervous system; Gen, genital; GI, gastrointestinal; GSE, general side effect burden; Vis vision.
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