Figure 4 | Translational Psychiatry

Figure 4

From: Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome

Figure 4

Increasing catechol-O-methytransferase (Comt) expression in the prefrontal cortex (PFC) rescues schizophrenia-like phenotypes of Df1/+ mice. (a, b, d, e) Enhanced response of male Df1/+ mice to MK801 (b) and SKF38393 (e) were normalized by lentivirus-mediated Comt overexpression in the PFC (a, d). SKF38393 (12 mg kg−1) and MK801 (0.32 mg kg−1) were injected subcutaneously and intraperitoneally, respectively, to the mice infected with Lenti-CAG-Comt (a, d) or control Lenti-CAG-GFP (b, e). Stereotypy count is shown in 5 min bins for 60 min after drug administration. Values are the mean±s.e.m. for 6–16 male mice. (c, f) Tolcapone, a Comt inhibitor, failed to reverse a therapeutic effect of Comt overexpression of the enhanced stereotypic response of Df1/+ mice to MK801 (c) and SKF38393 (f). Tolcapone (30 mg kg−1) was intraperitoneally injected to male Df1/+ mice 1 h before administration of MK801 (0.32 mg kg−1). Stereotypy count is shown in 5 min bins for 60 min after MK801 administration. Values are the mean±s.e.m. for 5–16 male mice.

Back to article page