Figure 6 | Translational Psychiatry

Figure 6

From: Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome

Figure 6

Normalization of the abnormal response of Df1/+ mice to SL651498 by lentivirus-mediated catechol-O-methytransferase (Comt) overexpression in the prefrontal cortex (PFC). (a–c) MK801 (0.32 mg kg−1) and (d–f) SL651498 (1 mg kg−1), GABAA α2/α3 receptor agonist, were injected intraperitoneally and SKF38393 (12 mg kg−1) was injected subcutaneously to the Lenti-CAG-Comt (a, d) or control Lenti-CAG-GFP (b, e)-infected Df1/+ and control mice. Stereotypy count is shown in 5 min bins for 60 min after drug administration (a, b, d, e) and quantification of stereotypy count for 60 min is shown in (c, f). Values are the mean±s.e.m. for 8–9 male mice. (c) *P=0.0000022, **P=0.00000076. (f) *P=0.0053.

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