Figure 1
Combined effect sizes for the associations between positive and negative environmental factors and child outcomes for the 5HTTLPR ss/sl and ll genotypes, in the total set of studies (except sl/ll, k=73) and in studies with >80% Caucasian participants (k=52). *P<0.05, **P<0.01. Note: In the total set of studies, the combined effect sizes for positive environmental factors are significant for both ss/sl and ll carriers. The difference between the combined effect sizes for ss/sl and ll is not significant, Qcontrast=0.54, P=0.46. The combined effect size for negative environmental factors is significant for ss/sl carriers, but not for ll carriers. The combined effect sizes for ss/sl and ll differ significantly, Qcontrast=8.35, P<0.01. In the set of studies with mostly Caucasian participants, the combined effect sizes for positive and negative environmental factors are significant for the ss/sl carriers, but not for the ll carriers. The differences between the combined effect sizes for ss/sl and ll carriers are significant, Qcontrast=3.92, P=0.048 for positive environmental factors and Qcontrast=4.58, P=0.03 for negative environmental factors.
