Figure 2

Concept of molecular network in schizophrenia. The network showed associations between the five candidate metabolites and the schizophrenia risk genes. For details, see Supplementary Table 2. Node shaped as circle, square, octagon and diamond represent metabolite, enzyme, intermediate protein and schizophrenia risk gene, respectively. Nodes overlaid with a color key representing their major functions: arginine, glutamine metabolism process and nitrogen compound biosynthetic process (yellow); signaling pathway (blue); memory or learning (purple); proliferation, apoptosis and focal adhesion (gray).