Table 2 Single-SNP association analysis, haplotype analysis and meta-analysis results of the five newly genotyped samples from the PanIC
From: Replication and meta-analysis of TMEM132D gene variants in panic disorder
Samples | ACG | Tartu | IT | NIMH | Japan | Combined |
|---|---|---|---|---|---|---|
Number of cases | 460 | 217 | 165 | 77 | 760 | 1679 |
Number of controls | 856 | 285 | 163 | 192 | 770 | 2266 |
SNPs | ||||||
rs7309727 | ||||||
P-value | 0.001 | 0.5 | 0.7 | 0.05 | 0.4 | 0.41 |
OR (CI) | 1.36 (1.13–1.65) | 1.09 (0.82–1.47) | 0.95 (0.66–1.36) | 0.63 (0.39–1.0) | 0.94 (0.81–1.09) | 1.04 (0.93–1.16) |
rs11060369 | ||||||
P-value | 0.9 | 0.6 | 0.01 | 0.6 | 0.8 | 0.28 |
OR (CI) | 0.99 (0.83–1.18) | 0.92 (0.7–1.21) | 0.67 (0.49–0.94) | 0.90 (0.61–1.32) | 0.98 (0.85–1.14) | 0.94 (0.87–1.04) |
rs9804847 | ||||||
P-value | 0.9 | 0.3 | 0.05 | 0.17 | 0.2 | 0.97 |
OR (CI) | 1.0 (0.85–1.18) | 1.15 (0.88–1.49) | 0.72 (0.52–1.01) | 0.77 (0.53–1.11) | 1.21 (0.93–1.58) | 0.99 (0.89–1.11) |
rs4759958 | ||||||
P-value | 0.07 | 0.8 | 0.1 | 0.7 | 0.3 | 0.036 |
OR (CI) | 1.17 (0.98–1.38) | 0.96 (0.73–1.28) | 0.28 (0.93–1.75) | 1.07 (0.73–1.60 | 1.07 (0.93–1.24) | 1.11 (1.0–1.23) |
Haplotype rs7309727–rs11060369 | ||||||
Omnibus test | 0.0054 | 0.81 | 0.21 | 0.037 | 0.33 | 0.47 |
CC | ||||||
P-value | 0.69 | 0.54 | 0.02 | 0.51 | 0.82 | 0.77 |
OR (CI) | 0.98 (0.82–1.17) | 0.92 (0.70–1.21) | 0.67 (0.49–0.94) | 0.99 (0.82–1.17) | 0.98 (0.81–1.1) | 0.99 (0.90–1.08) |
TA | ||||||
P-value | 0.0023 | 0.5 | 0.7 | 0.057 | 0.37 | 0.036 |
OR (CI) | 1.36 (1.12–1.65) | 1.1 (0.81–1.49) | 0.95 (0.66–0.37) | 0.63 (0.4–1.0) | 0.93 (0.81–1.08) | 1.11 (0.10–1.24) |
CA | ||||||
P-value | 0.006 | 0.9 | 0.01 | 0.017 | 0.16 | 0.064 |
OR (CI) | 0.79 (0.67–0.93) | 1.0 (0.99–1.01) | 1.5 (1.1–2.05) | 1.6 (1.1–2.39) | 1.15 (0.95–1.39) | 0.91 (0.84–1.0) |
