Figure 1

Schematic representation of putative DNA methylation/demethylation pathways. AID/APOBEC, activation-induced deaminase/apolipoprotein B RNA-editing catalytic component; BER, base excision repair; C, cytosine; DNMT, DNA methyltransferase; 5hmC, 5-hydroxylmethylcytosine; 5hmU, 5-hydroxylmethyluracil; 5mC, 5-methylcytosine; TDG, thymine DNA glycosylase; TET, ten-eleven translocation protein.