Table 1 Summary of the TET1, TET2 and TET3 mRNA expression in the IPL (parietal cortex) and the cerebellum of CTR subjects and DEP and PSY patients

From: Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients

Variable (mRNA)

Patient cohort

Overall ANOVA

Multiple comparison

 

1 CTR

2 DEP

3 PSY

F

d.f.

P-value

DEP vs

PSY vs

       

1

3

1

2

Parietal cortex

 TET1

0.64±0.09

1.02±0.18

1.29±0.10

7.656

2

0.002

—

—

0.00.1

—

 TET2

1.38±0.15

2.0±0.24

1.93±0.23

1.786

2

NS

—

—

—

—

 TET3

0.91±0.16

1.23±0.14

1.28±0.11

2.187

2

NS

—

—

—

—

Cerebellum

 TET1

3.45±0.49

2.95±0.44

3.28±0.27

1.843

2

NS

—

—

—

—

  1. Abbreviations: CTR, nonpsychiatric; DEP, depressed; d.f., degree of freedom; IPL, inferior parietal lobule; NS, nonsignificant; PSY, psychotic; TET, ten-eleven translocation protein.
  2. TET1 mRNA expression was significantly increased in the PSY group compared with the CTR group. Each value represents the mean±s.e.m. of relative quantity (2−ΔCt × 10−2) of TET mRNA vs β-actin mRNA
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