Figure 1
From: FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo
Pharmacologic blockade of (5-lipoxygenase-activating protein, FLAP) decreases tau phosphorylation in the brains of Tg2576 mice. (a) Representative western blot analyses for endogenous total mouse tau, phosphorylated tau as recognized by the antibodies; PHF-1, PHF-13, AT180, AT8, AT270 in brain cortex homogenates of Tg2576 mice receiving MK-591 or placebo. (b) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (n=9 for control and n=11 for MK-591; *P=0.02). (c) Representative western blot analyses for insoluble tau in brain cortex homogenates of Tg2576 mice receiving MK-591 or placebo (control). (d) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P=0.04). Results are mean±s.e.m.
