Figure 2
From: FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo
Pharmacologic blockade of 5-lipoxygenase-activating protein (FLAP) reduces tau phosphorylation immunoreactivity. (a) Representative sections of brains from Tg2576 mice receiving MK-591 or placebo (control) immunostained for total tau, PHF-13, PHF-1 and AT280-positive areas (x40 magnification). (b) Quantification of the area occupied by the immunoreactivity to the same antibodies shown in the previous panel (*P<0.01).
