Figure 4
From: FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo
Improvement of synaptic integrity by MK-591. (a) Representative western blot analysis for synaptophysin, post-synaptic density protein -95 (PSD-95) and dendritic protein microtubule-associated protein 2 (MAP-2) in brain cortex homogenates of Tg2576 mice treated with MK-591 or placebo (control). (b) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P<0.05). (c) Representative sections of brains from Tg2576 mice receiving MK-591 or placebo (control) immunostained for synaptophysisn, PSD-95 and MAP-2 (x40 magnification). (d) Quantification of the area occupied by the immunoreactivity to the same antibodies shown in the previous panel (*P<0.05). Results are mean±s.e.m.
