Table 3 MANEA rs1133503 genotype is associated with panic disorder and generalized social anxiety disorder diagnosis in different European American samples

From: The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder

Group

Genotype count (frequency)

Odds ratio (95% CI) a

P-value

 

TT

CT

CC

  

Sample 1 - panic disorder

Cases

49 (25.7%)

107 (56.0%)

35 (18.3%)

  
 

Controls

694 (36.9%)

867 (46.1%)

321 (17.1%)

1.7 (1.21–2.40)b

0.002

Sample 2 - panic disorder

Cases

36 (25.4%)

74 (52.1%)

32 (22.5%)

  
 

Controls

188 (34.2%)

268 (48.7%)

94 (17.1%)

1.53 (1.01–2.33)c

0.043

Sample 3 - GSAD

Cases

28 (21.4%)

87 (66.4%)

16 (12.2%)

  
 

Controls

74 (36.6%)

96 (47.5%)

32 (15.8%)

2.15 (1.27–3.64)d

0.004

  1. Abbreviation: GSAD, generalized social anxiety disorder.
  2. aRisk associated with carrying the C-allele of rs1133503.
  3. bAdjusted for sex, age and cocaine-induced paranoia.
  4. cAdjusted for sex and age.
  5. dAdjusted for sex.