Figure 1 | Translational Psychiatry

Figure 1

From: Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala

Figure 1

Conceptual framework and behavioral effects of environmental modifications. The triangle reflects the anxiety continuum with HAB and LAB representing its extremes and HAB-EE and LAB-chronic mild stress (CMS) the environmentally driven shifts toward ‘normal’ (a). ‘Normal’ anxiety (dashed line) indicates behavior of normal anxiety-related behavior mice (NAB), bred in parallel with LAB and HAB mice, with percent time spent on the open arms of the elevated plus-maze in the 35–45% range. Enriched environment (EE) significantly decreased and CMS increased percent time spent in the light compartment of the light–dark (LD) box (b) and open arms of the elevated plus maze (c) (n=8–12 animals per group). High and low anxiety after environmental manipulations is not associated with decreased or increased home cage locomotion after EE (d) or CMS (e) (n=8 animals per group). Bars represent mean+s.e.m. *P<0.05, **P<0.01 (MWU).

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