Figure 1 | Translational Psychiatry

Figure 1

From: Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

Figure 1

Black arrows: (a) The linkage disequilibrium (LD) block in sortilin-related VPS10 domain-containing receptor 3 (SORCS3) showing significant interaction with (b) two specific LD blocks in SORCS2 and (c) one specific LD block in SORCS1. Red arrows: Additional single nucleotide polymorphisms (SNPs) showing epistasis between SORCS2 and SORCS3. (a) The single LD block in SORCS3 showing epistasis with two specific LD blocks in SORCS2 (Figure 3b) and one specific LD block in SORCS1 (Figure 3c). (b) The two specific two LD blocks in SORCS2 (black arrows) showing epistasis with SORCS3, and SNPs showing in addition epistasis with SORCS1 (red arrows). (c) The specific LD block in SORCS1 (black arrows) showing epistasis with the specific LD block in SORCS3, and SNPs showing epistasis with SNPs in SORCS2 (red arrows).

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