Figure 2 | Translational Psychiatry

Figure 2

From: Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

Figure 2

(a) View of sortilin-related VPS10 domain-containing receptor 3 (SORCS3) exon expression profile in 19 Alzheimer’s disease (AD; red triangles) and 10 control (CTRL; blue squares) amygdala tissue. Each triangle dot represents least squares mean expression of an exon in AD tissue; each square dot represents least squares mean expression of an exon in control tissue. The mean gene expression intensity of AD vs controls was 4.17±0.43 vs 5.03±0.49 (P=5.1E-5) across all exons. (b) View of SORCS2 exon expression profile in 19 AD (red triangles) and 10 control (blue squares) amygdala tissue. Each triangle dot represents least squares mean expression of an exon in AD tissue; each square dot represents least squares mean expression of an exon in control tissue. The mean gene expression intensity of AD vs controls was 5.29±0.33 vs 5.08±0.32 (P=0.12) across all exons. (c) View of sortilin 1 (SORT1) exon expression profile in 19 AD (red triangles) and 10 control (blue squares) amygdala tissue. Each triangle dot represents least squares mean expression of an exon in AD tissue; each square dot represents least squares mean expression of an exon in control tissue. The mean gene expression intensity of AD vs controls was 9.43±0.38 vs 9.21±0.39 (P=0.17) across all exons.

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