Figure 5
High cue reactive (HCR) rats exhibit lower sensitivity to the suppressive effects of the selective 5-HT2CR agonist WAY163909 relative to low cue reactive (LCR) rats. Mean active lever presses (±s.e.m.) are presented for the cue reactivity test session. Each previously active lever press resulted in the presentation of the discrete cue complex in the absence of cocaine delivery on an FR1. Rats identified as HCR (n=16 rats per treatment) and LCR rats (n=16 rats per treatment) were injected with saline (15 min; 1 ml kg−1, intraperitoneal) or WAY163909 (15 min; 0.5 mg kg−1; intraperitoneal) prior to a cocaine cue reactivity test session on FA day 1. WAY163909 significantly attenuated lever presses for cocaine-associated cues in LCR, but not HCR, rats (*P<0.05 vs saline-treated LCR rats). FA, forced abstinence.
