Figure 1 | Translational Psychiatry

Figure 1

From: Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder

Figure 1

Whole-brain significant task effects. (a) Significant whole-brain analysis of high versus low pain anticipation in the non-MDD (left), MDD (middle) and between-group contrast (right) showed increased bilateral dorsal AI activation in both groups and increased activation within ventral portion of the rAI in MDD (see Tables 2, 3, 4 for further details). (b) Whole-brain conjunction of high versus low pain anticipation in MDD (purple) and non-MDD (green) groups showed significant overlap (yellow) in right dorsal AI (x/y/z: 37/21/5, 512 mm3). Bar graphs indicate percent signal change within right dorsal AI during anticipation of low and high pain in MDD and non-MDD group. Left=Right. Non-MDD, healthy, never-depressed controls.

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