Table 2 High–low pain anticipation: non-MDD group whole brain

From: Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder

Brain region

Volume

x

y

z

Stat

High>low pain anticipation

 R. insula/IFG (BA 45)

5184

32

28

6

2.66

 L. insula (BA 13)

1216

−35

21

14

2.53

 R. IFG (BA 9)

1792

48

15

24

2.68

 R. MFG (BA 9)

1408

41

12

34

2.72

 R. IPL (BA 40)

2752

53

−46

32

2.61

 L. cingulate (BA 23)

1472

−1

−38

24

2.63

 R. MTG (BA 22)

1216

54

−38

3

2.68

 R. STG (BA 22)

1024

48

−19

−5

2.52

 R. caudate

768

11

9

11

2.83

 Cerebellar vermis

768

−3

−29

−12

2.84

 L. cerebellar tonsil

896

−38

−46

−37

2.45

Low>high pain anticipation

 R. parahippocampal gyrus

832

26

−30

−13

2.73

 L. precentral gyrus

768

−49

−13

31

2.46

  1. Abbreviations: BA, Brodmann area; IFG, inferior frontal gyrus; IPL, inferior parietal lobule; L., left; MFG, medial frontal gyrus; MTG, medial temporal gyrus; non-MDD, never-depressed controls; R., right; STG, superior temporal gyrus.