Table 2 Difference in mean CHRM1 DNA methylation at individual CpG units for schizophrenia vs control groups (after adjustment for death by suicide, sex, age, pH and PMI)
CpG unit | Genome coordinate | Number | Methylation | Difference (Sz minus Controls) | |||||
|---|---|---|---|---|---|---|---|---|---|
Sz | Control | Sz | Control | Δ Mean Methylation | P | 95% CI | |||
chrm1_0401_CpG2 | 62445428 | 56 | 54 | 16.0% | 17.9% | −2.9% | 0.17 | −7.0% | 1.2% |
chrm1_0401_CpG3 | 62445440 | 64 | 60 | 7.3% | 7.4% | −0.4% | 0.55 | −1.8% | 1.0% |
chrm1_0304_CpG2 | 62445521 | 55 | 49 | 15.8% | 17.0% | −2.2% | 0.072 | −4.5% | 0.2% |
chrm1_0304_CpG4 | 62445617 | 48 | 44 | 25.6% | 28.0% | −5.3% | 0.006 | −9.1% | −1.5% |
chrm1_0304_CpG5_6 | 62445641 | 54 | 52 | 18.7% | 20.8% | −3.2% | 0.017 | −5.9% | −0.6% |
chrm1_06_CpG2 | 62445645 | 58 | 55 | 15.1% | 16.4% | −2.7% | 0.010 | −4.8% | −0.6% |
chrm1_06_CpG3_4 | 62445657 | 63 | 60 | 15.2% | 15.7% | −0.9% | 0.32 | −2.5% | 0.8% |
chrm1_06_CpG7 | 62445700 | 61 | 56 | 26.7% | 26.8% | −1.1% | 0.34 | −3.4% | 1.2% |
chrm1_06_CpG8 | 62445953 | 58 | 57 | 32.8% | 34.5% | −2.4% | 0.046 | −4.9% | 0.0% |
chrm1_06_CpG9 | 62445992 | 59 | 55 | 41.7% | 44.1% | −2.6% | 0.075 | −5.4% | 0.3% |
