Table 3 Difference in mean methylation for Def and Non-Def schizophrenia groups minus controls at individual CpG units (after adjustment for sex, age pH, PMI and death by suicide)
CpG unit | Genome coordinate | Number | Def-Sz vs controls | Non-Def-Sz vs controls | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sz | Control | Δ Mean methylation | P | 95% CI | Δ Mean methylation | P | 95% CI | |||||
Def | Non-Def | |||||||||||
chrm1_0401_CpG2 | 62445428 | 18 | 38 | 54 | −3.9% | 0.12 | −8.8% | 1.0% | −2.2% | 0.34 | −6.8% | 2.4% |
chrm1_0401_CpG3 | 62445440 | 20 | 44 | 60 | −0.7% | 0.40 | −2.4% | 1.0% | −0.2% | 0.78 | −1.8% | 1.3% |
chrm1_0304_CpG2 | 62445521 | 16 | 39 | 49 | −2.5% | 0.08 | −5.4% | 0.3% | −1.9% | 0.16 | −4.5% | 0.7% |
chrm1_0304_CpG4 | 62445617 | 14 | 34 | 44 | −6.8% | <0.01 | −11.6% | −2.1% | −4.4% | 0.04 | −8.6% | −0.3% |
chrm1_0304_CpG5_6 | 62445641 | 16 | 38 | 52 | −3.8% | 0.02 | −7.1% | −0.6% | −2.8% | 0.07 | −5.7% | 0.2% |
chrm1_06_CpG2 | 62445645 | 17 | 41 | 55 | −3.1% | 0.01 | −5.5% | −0.6% | −2.4% | 0.04 | −4.7% | −0.1% |
chrm1_06_CpG3_4 | 62445657 | 20 | 43 | 60 | −0.8% | 0.42 | −2.9% | 1.2% | −0.9% | 0.37 | −2.8% | 1.0% |
chrm1_06_CpG7 | 62445700 | 20 | 41 | 56 | −1.0% | 0.46 | −3.7% | 1.7% | −1.2% | 0.36 | −3.8% | 1.4% |
chrm1_06_CpG8 | 62445953 | 17 | 41 | 57 | −2.1% | 0.16 | −5.0% | 0.8% | −2.7% | 0.05 | −5.4% | 0.0% |
chrm1_06_CpG9 | 62445992 | 20 | 39 | 55 | −2.2% | 0.19 | −5.5% | 1.1% | −2.9% | 0.08 | −6.1% | 0.3% |