Table 3 Difference in mean methylation for Def and Non-Def schizophrenia groups minus controls at individual CpG units (after adjustment for sex, age pH, PMI and death by suicide)

From: Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

CpG unit

Genome coordinate

Number

Def-Sz vs controls

Non-Def-Sz vs controls

  

Sz

Control

Δ Mean methylation

P

95% CI

Δ Mean methylation

P

95% CI

  

Def

Non-Def

         

chrm1_0401_CpG2

62445428

18

38

54

−3.9%

0.12

−8.8%

1.0%

−2.2%

0.34

−6.8%

2.4%

chrm1_0401_CpG3

62445440

20

44

60

−0.7%

0.40

−2.4%

1.0%

−0.2%

0.78

−1.8%

1.3%

chrm1_0304_CpG2

62445521

16

39

49

−2.5%

0.08

−5.4%

0.3%

−1.9%

0.16

−4.5%

0.7%

chrm1_0304_CpG4

62445617

14

34

44

−6.8%

<0.01

−11.6%

−2.1%

−4.4%

0.04

−8.6%

−0.3%

chrm1_0304_CpG5_6

62445641

16

38

52

−3.8%

0.02

−7.1%

−0.6%

−2.8%

0.07

−5.7%

0.2%

chrm1_06_CpG2

62445645

17

41

55

−3.1%

0.01

−5.5%

−0.6%

−2.4%

0.04

−4.7%

−0.1%

chrm1_06_CpG3_4

62445657

20

43

60

−0.8%

0.42

−2.9%

1.2%

−0.9%

0.37

−2.8%

1.0%

chrm1_06_CpG7

62445700

20

41

56

−1.0%

0.46

−3.7%

1.7%

−1.2%

0.36

−3.8%

1.4%

chrm1_06_CpG8

62445953

17

41

57

−2.1%

0.16

−5.0%

0.8%

−2.7%

0.05

−5.4%

0.0%

chrm1_06_CpG9

62445992

20

39

55

−2.2%

0.19

−5.5%

1.1%

−2.9%

0.08

−6.1%

0.3%

  1. Abbreviations: CI, confidence interval; chrm1, cortical muscarinic M1 receptors; Def-Sz, [3H]pirenzepine binding deficient schizophrenia; Non-Def-Sz, subjects with schizophrenia without deficits in [3H]pirenzepine binding; Sz, schizophrenia.
  2. Bold entries indicate P<0.05.