Table 4 Predictors of CHRM1 DNA methylation

From: Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

CHRM1 DNA methylation

Covariate

Coefficient

P

95% CI

Schizophrenia vs controls

 Schizophrenia

−2.2%

<0.01

−3.8%

−0.6%

 Suicide

1.7%

0.09

−0.3%

3.7%

 Sex (males minus females)

−0.5%

0.53

−2.0%

1.0%

 Age (z-score)

−0.4%

0.33

−1.1%

0.4%

 pH (z-score)

−0.4%

0.36

−1.2%

0.4%

 Post mortem interval (z-score)

−0.1%

0.86

−0.8%

0.7%

Def-Sz, non-Def-Sz and controls

 non-Def_Sz minus controls

−2.0%

0.03

−3.9%

−0.2%

 Def_Sz minus controls

−2.4%

0.02

−4.5%

−0.4%

 Def-Sz minus non-Def-Sz

−0.4%

0.70

−2.5%

1.7%

  1. Abbreviations: CI, confidence interval; Def-Sz, [3H]pirenzepine binding deficient schizophrenia; Non-Def-Sz, subjects with schizophrenia without deficits in [3H]pirenzepine binding; Sz, schizophrenia.
  2. Bold entries indicate P<0.05.
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