Table 1 Family-based association tests for ANK3 variants and haplotypes under additive model

From: Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations

Marker

Over-transmitted

Allele frequency

Z-score

P-value

Adjusted P-valuea

rs1380455

T

0.728

2.108

0.035

0.193

rs16914968

T

0.076

1.643

0.100

0.470

rs1551684

C

0.914

1.111

0.267

0.844

rs3808942

T

0.745

0.094

0.925

1.000

rs3808943

T

0.311

2.430

0.015

0.087

rs10994336

T

0.310

1.939

0.053

0.276

Haplotype

Informative families

Haplotype frequency

Z -score

P -value

Permutation P -value b

TCCTTT

103

0.315

2.266

0.023

0.035*

GCCTCC

111

0.279

−1.572

0.116

0.126

TCCCCC

100

0.247

−0.565

0.572

0.552

TCTTCC

43

0.070

−0.778

0.436

0.396

TTCTCC

39

0.069

1.737

0.082

0.079

  1. Abbreviation: ANK3, ankyrin-G.
  2. aBonferroni-adjusted P-values.
  3. bP-values derived from 10 000 permutations; *denotes statistical significance.
  4. Non-adjusted P-values <0.05 are in bold.
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