Figure 4
From: Autism-specific maternal autoantibodies recognize critical proteins in developing brain
Schematic model depicting the neurodevelopmental roles for each of the maternal autoantibody target proteins. Disruption of protein function or quantity may negatively alter neurodevelopment, potentially leading to the core features associated with autism. There is likely an additive effect as illustrated by the autism spectrum disorder specificity of the various autoantibody combinations. CRMP, collapsin response mediator protein; LDH, lactate dehydrogenase; STIP1, stress-induced phosphoprotein 1; YBX1, Y-box-binding protein.
