Figure 11

Heatmap and Canonical Correspondence Analysis on Microarray data of brain from wild-type (WT), RAG-1^−/− and RAG-1^–/–/OT-II mice. (a) Genes were filtered by a moderated t-statistics and fold change (FC). The heatmap analysis used annotated genes only (genes with EntrezID). (b) Hierarchical clustering and heatmap analysis of the filtered genes. RAG-1^−/− samples showed a distinct cluster. (c) Similarity analysis for the features of RAG-1^−/− in comparison with WT. Note that RAG-1^−/−/OT-II mice had low scores and were equivalent to WT mice.