Table 1 Basic characteristics of the discovery and replication data sets

From: Alcohol-induced metabolomic differences in humans

 

Discovery KORA F4 (n=2090)

Replication KORA F3 (n=261)

Replication TwinsUK (n=277)

 

Male (n=1144)

Female (n=946)

Male (n=154)

Female (n=107)

Female (n=277)a

 

LD b

MHD c

P-value

LD

MHD

P-value

LD

MHD

P-value

LD

MHD

P-value

LD

MHD

P-value

Participants, n (%)

859 (75)

285 (25)

—

712 (75)

234 (25)

—

106 (69)

48 (31)

—

84 (78)

23 (22)

—

250 (90)

27 (10)

—

Age (years) mean±s.d.

56.2±13.7

57.1±11.6

2.8E−01d

54.5±13.2

55.7±11.5

1.8E−01d

67.9±7.6

64.5±6.8

1.3E−02d

65.5±7.4

64.6±7.7

5.3E−01d

48.4±10.2

43.5±9.0

1.6E−02d

BMI(kg m−2) mean±s.d.

27.6±3.8

28.4±4.2

3.4E−03d

26.6±4.9

26.3±4.7

3.6E−01d

28.1±3.1

29.1±3.6

1.2E−01d

27.6±3.7

27.5±4.0

9.5E−01d

25.1±4.6

24.7±4.1

8.1E−01d

Smoker, n (%)

153 (18)

66 (23)

1.0E−04e

103 (14)

44 (19)

1.2E−01e

8 (7)

8 (17)

9.5E−02e

4 (5)

3 (13)

1.7E−01e

67 (27)

14 (52)

1.3E−02e

HDL (mg dl−1) mean±s.d.

49.9±11.3

55.8±13.5

7.1E−12d

62.7±13.6

66.0±15.0

4.4E−03d

49.2±13.2

59.3±15.3

1.5E−04d

65.7±16.7

71.10±16.2

1.4E−01d

58.9±14.5

66.2±13.9

1.3E−02d

Triglyceride (mg dl−1) mean±s.d.

134.5±82.0

154.0±104.9

3.4E−02e

103.9±71.4

100.9±53.6

9.7E−01e

188.0±106.7

192.3±130.2

9.6E−01e

156.2±74.1

146.4±85.0

3.0E−01e

99.6±47.3

94.1±71.4

1.1E−01d

  1. Abbreviations: BMI, body mass index; HDL, high-density lipoprotein; LD, light drinkers; MHD, moderate-to-heavy drinkers.
  2. Significant P-values are in bold.
  3. a629 participants were available for replication analysis; for 277 participants HDL-C and triglyceride data were available.
  4. bAlcohol consumption<40g day−1 males,<20g day−1 females.
  5. cAlcohol consumption⩾40 g day−1 males,⩾20 g day−1 females.
  6. dMann–Whitney test (two-sided).
  7. eFisher’s exact test (two-sided), significance level α=0.05.
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