Table 1 Characteristics of the discovery and replication samples

From: Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression

 

Discovery sample

Replication sample

Characteristics

(n=124)

(n=665)

Female %

74

56

Age (range)

44.5 (21–63)

20.5 (18–40)

Depression scorea

3.6 (0–9)

5.4 (0–34)

Caucasian %

100

100

MTHFR C677T genotype (rs1801133)

 T/T, %

12

10

 T/C, %

40

43

 C/C, %

48

47

HWE (P-value)

0.32

0.94

Childhood traumab

44

1.4 (1.0–4.3)

  1. Abbreviations: HWE, Hardy–Weinberg equilibrium; MTHFR, methylenetetrahydrofolate reductase.
  2. aDiscovery sample: Hamilton depression rating scale (HDRS) total score; replication sample: Beck Depression Inventory (BDI) total score.
  3. bDiscovery sample: percent experienced traumatic childhood event(s) (TCE); replication sample: total score Childhood Trauma Questionnaire (CTQ).
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