Table 3 Effect of MTHFR modified by TCE in the discovery sample

From: Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression

 

β

s.e. β

Wald

d.f.

P-value

RR

MTHFR

−0.081

0.284

0.080

1

0.777

0.923

TCE

0.368

0.296

1.544

1

0.214

1.445

MTHFR × TCE a

0.979

0.410

5.713

1

0.017

2.663

  1. Abbreviations: MTHFR, methylenetetrahydrofolate reductase; TCE, traumatic childhood event; RR, relative risk.
  2. Cox regression analysis.
  3. MTHFR: T-allele carrying patients versus non-T-allele carrying patients, with non-T-allele carriers as the reference category.
  4. TCE: experienced TCE yes/no, with no TCE as the reference category.
  5. aP=0.016 after adjustment for age, gender and antidepressant (AD) use.
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